Peroxisome proliferator-activated receptors and inflammation: from basic science to clinical applications
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چکیده
منابع مشابه
Peroxisome Proliferator-activated Receptors
Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-activated nuclear hormone receptor superfamily of transcription factors that includes receptors for steroids, thyroid hormone, retinoic acid, and vitamin D. Upon activation in the cytoplasm, PPARs heterodimerize with retinoid X receptors (RXR) and form a complex that translocates to the nucleus and regulates gene expr...
متن کاملPeroxisome proliferator-activated receptors as therapeutic targets in inflammation.
For decades, advances in endocrinology were characterized by a process in which hormones were first identified based upon their physiologic roles and then purified, often from vast quantities of biologic material. This purified material was then used to identify the receptors through which the hormone signaled. In this classic progression, science moved from physiology to cellular signaling. Mo...
متن کاملRole of Peroxisome Proliferator-Activated Receptors in Inflammation Control
Peroxisome proliferator-activated receptors (PPARs) were discovered over a decade ago, and were classified as orphan members of the nuclear receptor superfamily. To date, three PPAR subtypes have been discovered and characterized (PPAR $\alpha$, $\beta/\delta$, $\gamma$ ). Different PPAR subtypes have been shown to play crucial roles in important diseases and conditions such as obesity, diabete...
متن کاملPeroxisome proliferator-activated receptors: from genes to physiology.
The peroxisome proliferator-activated receptors (PPARalpha, gamma, delta) are members of the nuclear receptor superfamily of ligand-activated transcription factors that have central roles in the storage and catabolism of fatty acids. Although the three PPAR subtypes are closely related and bind to similar DNA response elements as heterodimers with the 9-cis retinoic acid receptor RXR, each subs...
متن کاملPeroxisome proliferator-activated receptors and cardiovascular remodeling.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that heterodimerize with the retinoid X receptor and then modulate the function of many target genes. Three PPARs are known: alpha, beta/delta, and gamma. The better known are PPAR-alpha and PPAR-gamma, which may be activated by different synthetic agonists, although the endogenous ligands are unknown. PPAR-alpha is invol...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2003
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0802499